Depression.
The most heavily funded area of psilocybin research, and the one closest to regulatory approval. Note how often the comparison group also improves, and how the effect shrinks once reviewers correct for it.
9 studies · 1 early · 4 moderate · 4 strongWhat psilocybin therapy would have to cost to be worth it
Only the highest dose eased treatment-resistant depression
In ordinary depression, psilocybin beat placebo by twelve points
Psilocybin and a standard antidepressant, with no clear winner
Two sessions, and most participants halved their depression
A year later, most of them were still better
Psilocybin survived the placebo correction, but the effect shrank to small
Depression scores fell seventeen points in the hardest cases
Every trial in this section used a single large dose, given in a clinic, with trained people in the room for the whole session. That is a different activity from anything sold on this site. More on why that distinction matters.
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