The Microgenix research library

Every psilocybin study worth reading, in one place.

Sixty-three studies on psilocybin, sorted by what they actually looked at and weighted by how much they actually prove. Every entry links straight to the source. We have included the trials that failed, the results that did not replicate, and the ones that undercut what we sell, because a shelf that only holds good news is an advert.Sixty-three studies, graded by how much each proves. The trials that failed are here too.

New here? The first fiveMicrodosing 8Depression 9Anxiety 6Addiction 9Cognition 6Ageing and injury 3Brain and plasticity 7Other conditions 9Safety 6
63Studies indexed
17Randomised trials
1998-2026Years covered
9Research areas
Aug 2026Last updated
How we grade the evidence
Start here

If you only read five.

A first pass across the territory. The landmark trials, the honest null result, and the safety read that frames all of it.

The cleanest positive trialIn ordinary depression, psilocybin beat placebo by twelve pointsStrong evidence2023The landmark trialFifty-one cancer patients, and six months of reliefStrong evidence2016The addiction standoutHeavy drinking days cut by more than halfStrong evidence2022The honest nullSelf-blinded microdosers improved, but so did the placebo groupStrong evidence2021The safety pictureNo serious harms in healthy people, some in psychiatric patientsStrong evidence2024
Browse by area

Nine areas, graded honestly.

Microdosing

8 studiesThe smallest doses have the least clinical evidence behind them, and the honest picture is mixed.1 early · 4 moderate · 3 strong

Depression

9 studiesThe most heavily funded area of psilocybin research, and the one closest to regulatory approval.1 early · 4 moderate · 4 strong

Anxiety and end of life distress

6 studiesThe oldest thread in the modern revival.2 early · 1 moderate · 3 strong

Addiction and habit change

9 studiesSmoking and alcohol have the strongest signals.3 early · 2 moderate · 4 strong

Mood, creativity and cognition

6 studiesStudies in healthy people rather than patients.1 early · 2 moderate · 3 strong

Cognition, ageing and brain injury

3 studiesThe newest and least settled corner of the field.3 early

The brain on psilocybin

7 studiesMechanism work explaining how a single dose can outlast the dose.3 early · 4 moderate

Other conditions

9 studiesEarly-stage work across OCD, eating disorders, headache and chronic pain.6 early · 3 moderate

Safety, dose and risk

6 studiesWhat the literature says about harm, tolerability and abuse potential.1 early · 3 moderate · 2 strong
Cover story

The Alzheimer's case report everyone is arguing about

One person. Which is exactly why it proves nothing, and exactly why it is worth reading.

NeurodegenerationCase report2026
Read the write-up
What the shelf actually holds

All 63 studies, weighted by how much they prove. Two thirds are early or moderate evidence.

  • 21Early signalcase reports, pilots,
    animal work
  • 23Moderateopen-label trials,
    large surveys
  • 19Strongrandomised trials,
    meta-analyses
How we grade

Three bars, weighted by proof.

Every study on the shelf carries a rating. It grades the design of the study, not whether we like the finding.

Strong evidence (19 studies)

Randomised controlled trials and meta analyses. Someone compared psilocybin against a placebo, or pooled every trial that did, and the result held.

Moderate evidence (23 studies)

Open label trials, long follow ups and large surveys. Real signals that have not yet faced a control group.

Early signal (21 studies)

Pilots, case reports and animal work. A reason to run a bigger study, not proof that something works in people.

Worth knowing

Two thirds of this shelf is early or moderate. That is the honest state of the field, and it is why null results and failed replications sit alongside the wins.

The research is moving fast. We read it so you can too.

New work lands most weeks and we update this page as it does. If you spot a study we have missed, or think we have described one unfairly, tell us and we will fix it.

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For education, not medical advice. Every write-up links back to the original source.
Nothing here is a claim that our products treat, cure or prevent any condition. Talk to a doctor before changing anything about your health.