Depression scores fell seventeen points in the hardest cases
What they did
Twelve adults whose depression had not responded to at least five previous treatments received a single 25mg dose of synthetic psilocybin, with therapy sessions before and after dosing.
What they found
Average depression scores fell by 17.2 points on the MADRS scale at twelve weeks. The five participants who also had PTSD improved considerably less than the rest.
Worth knowing
Open-label with twelve people and no control group, so this is a signal rather than a finding. The weaker response in the PTSD subgroup is the more useful detail here.
Aaronson et al. Single-Dose Psilocybin for Depression With Severe Treatment Resistance. American Journal of Psychiatry, 2025.
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depressionOnly the highest dose eased treatment-resistant depressiondepressionIn ordinary depression, psilocybin beat placebo by twelve pointsdepressionPsilocybin and a standard antidepressant, with no clear winnerEvery trial in this section used a single large dose, given in a clinic, with trained people in the room for the whole session. That is a different activity from anything sold on this site. More on why that distinction matters.
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