Psilocybin reduced cocaine use in its first controlled trial
What they did
Forty people with cocaine use disorder were randomly assigned to a single dose of psilocybin or an active placebo, each with weekly psychotherapy for a month before and after dosing, then followed for 180 days. The sample was 82.5 percent Black and 65 percent had annual incomes at or below $20,000.
What they found
The psilocybin group had substantially more cocaine-free days and lower relapse risk than the placebo group through the six month follow-up.
Worth knowing
Forty people, with 36 completing. The representation here matters because almost every other trial on this page recruited overwhelmingly white, higher-income participants, which limits how far any of their findings generalise.
Hendricks et al. Psilocybin in the Treatment of Cocaine Use Disorder, A Randomized Clinical Trial. JAMA Network Open, 2026.
Read the sourceKeep reading
smokingPsilocybin beat the nicotine patch four to onealcoholHeavy drinking days cut by more than halfalcoholOne dose after detox did not beat placebo for drinkingA lot of our customers arrive from the sober curious side rather than the psychedelic side. If that is you, the alcohol research below is the most relevant on the whole shelf. See what we make.
For education, not medical advice. Every write-up links back to the original source.
Nothing here is a claim that our products treat, cure or prevent any condition. Talk to a doctor before changing anything about your health.