Heavy drinking days cut by more than half
What they did
Adults with alcohol use disorder were randomly assigned to two doses of psilocybin or an active placebo, each combined with twelve weeks of psychotherapy, and followed for thirty-two weeks.
What they found
Heavy drinking days averaged 9.7 percent in the psilocybin group against 23.6 percent on placebo, a gap of 13.9 percentage points. No serious adverse events were reported.
Worth knowing
Diphenhydramine was used as the active placebo and does not feel like psilocybin, so blinding was likely imperfect. Everyone in both groups also received twelve weeks of therapy, which does a lot of work.
Bogenschutz et al. Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in Adult Patients With Alcohol Use Disorder. JAMA Psychiatry, 2022.
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smokingPsilocybin beat the nicotine patch four to onecocainePsilocybin reduced cocaine use in its first controlled trialalcoholOne dose after detox did not beat placebo for drinkingA lot of our customers arrive from the sober curious side rather than the psychedelic side. If that is you, the alcohol research below is the most relevant on the whole shelf. See what we make.
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