One dose after detox did not beat placebo for drinking
What they did
Swiss researchers gave thirty-seven people who had just completed alcohol withdrawal treatment either a single 25mg psilocybin dose or placebo, each with about five psychotherapy sessions, then tracked relapse over four weeks.
What they found
Abstinence duration did not differ significantly, at 16.8 days with psilocybin against 13.8 days on placebo. Craving, depression and quality of life did improve more in the psilocybin group.
Worth knowing
A null result on the primary outcome, included here deliberately. It suggests a single dose plus brief therapy is not enough for severe cases, which is useful information the positive trials do not give you.
Rieser et al. Psilocybin-assisted therapy for relapse prevention in alcohol use disorder. eClinicalMedicine, 2025.
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smokingPsilocybin beat the nicotine patch four to onecocainePsilocybin reduced cocaine use in its first controlled trialalcoholHeavy drinking days cut by more than halfA lot of our customers arrive from the sober curious side rather than the psychedelic side. If that is you, the alcohol research below is the most relevant on the whole shelf. See what we make.
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