Twenty-one women with anorexia, and symptoms that improved for a year
What they did
Imperial College London gave twenty-one adult women with longstanding anorexia nervosa three dosing sessions over six weeks in a fixed order, starting with a 1mg low-dose control followed by two 25mg sessions, with talk therapy throughout and assessments out to twelve months.
What they found
Eating disorder symptoms and motivation to change both improved significantly, with gains sustained at follow-up, though responses varied considerably from person to person. Twenty of twenty-one completed the active period.
Worth knowing
One participant had two serious safety events, both suicide attempts, in the months after the study ended. Investigators judged them unlikely to be related to the drug, and we report them here because a library that omits them is not a library. The fixed dose order also means order effects cannot be separated from dose effects.
Douglass et al. Psilocybin therapy for adult females with anorexia nervosa, pilot study. The British Journal of Psychiatry, 2026.
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OCDOne small trial is the entire case for psilocybin and OCDcluster headacheCluster headaches dropped on psilocybin, but not significantlyOCDNine people with OCD, and symptoms that dropped within hoursWe include the trials that missed their endpoints alongside the ones that hit. A shelf that only holds good news is a marketing page, not a library.
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