cluster headacheFull doseFullModerate evidence

Cluster headaches dropped on psilocybin, but not significantly

A large-looking drop in attacks that did not reach significance.

2022Published

Randomised double-blind placebo-controlled exploratory trialStudy type

30 enrolledSample

What they did

Adults with cluster headache were randomised to three doses of psilocybin about five days apart or to placebo, then kept headache diaries for eight weeks.

What they found

Cluster attack frequency changed by minus 3.2 attacks per week with psilocybin against roughly zero on placebo. The difference did not reach statistical significance, though the chronic cluster headache subgroup showed a larger effect.

Not significanton the primary endpoint

-3.2attacks per week, psilocybin group

Worth knowing

This trial did not succeed. It is included because it is the only randomised placebo-controlled evidence in cluster headache, and because the raw numbers get quoted without the p value attached.

Schindler et al. Exploratory investigation of a patient-informed low-dose psilocybin pulse regimen in the suppression of cluster headache. Headache, 2022.

Read the source

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