OCDMicro + fullBothEarly signal

Nine people with OCD, and symptoms that dropped within hours

The only real trial that exists, and it is nearly twenty years old.

2006Published

Small modified double-blind dose-escalation studyStudy type

9 peopleSample

What they did

Nine adults with obsessive-compulsive disorder received up to four single doses of psilocybin ranging from sub-perceptual to clearly psychoactive levels, spread over several weeks.

What they found

All nine showed marked reductions in OCD symptom scores during test sessions, with decreases ranging from 23 to 100 percent. No serious adverse events were reported.

9participants, total

23 to 100%symptom reduction range

Worth knowing

Nine people, no placebo arm, and the very low dose reduced symptoms too, which undercuts any dose-response reading. Everything else published on psilocybin and OCD is case reports going back to the 1960s.

Moreno et al. Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder. Journal of Clinical Psychiatry, 2006.

Read the source

Keep reading

eating disordersTwenty-one women with anorexia, and symptoms that improved for a year OCDOne small trial is the entire case for psilocybin and OCD cluster headacheCluster headaches dropped on psilocybin, but not significantly

We include the trials that missed their endpoints alongside the ones that hit. A shelf that only holds good news is a marketing page, not a library.

Browse the library

Microdosing 8 Depression 9 Anxiety 6 Addiction 9 Cognition 6 Ageing and injury 3 Brain and plasticity 7 Other conditions 9 Safety 6 All research 63

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