neuroplasticityMechanismMechEarly signal

Psychedelics grew neurons in a dish, a fly and a rat

Effects comparable to ketamine, in three different preparations.

2018Published
Preclinical study in cell cultures, fruit flies and ratsStudy type
Cells and animalsSample
What our evidence ratings mean

What they did

Working across cultured rat nerve cells, fruit fly larvae and live rats, researchers tested whether classic psychedelics change the physical structure of neurons in the prefrontal cortex.

What they found

This preclinical study found increased branching, spine growth and working synaptic connections, with effects comparable to ketamine and dependent on specific signalling pathways.

3model systems tested

Worth knowing

No humans were involved at any point. This paper is the source of the word neuroplasticity in most psilocybin marketing, including marketing that does not mention the fruit flies.

Ly et al. Psychedelics Promote Structural and Functional Neural Plasticity. Cell Reports, 2018.

Read the source

This is where the word neuroplasticity comes from in psilocybin marketing. Worth reading the actual studies, because most of them were done in mice.

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