Activity went down, not up
What they did
Thirty healthy volunteers received intravenous psilocybin or placebo while blood flow and activity across the brain were measured with two different MRI methods.
What they found
Activity decreased rather than increased, with the largest drops in hub regions such as the medial prefrontal and cingulate cortex. The size of the decrease predicted how intense the subjective experience was.
Worth knowing
Intravenous dosing produces a much sharper onset than anything taken orally, so this describes a somewhat different experience from a swallowed dose.
Carhart-Harris et al. Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. PNAS, 2012.
Read the sourceKeep reading
brain networksPsilocybin disrupted brain communication far more than a stimulantbrain networksBrains became less compartmentalised, and moods lifted with themreceptorsBlocking one receptor switched the whole experience offThis is where the word neuroplasticity comes from in psilocybin marketing. Worth reading the actual studies, because most of them were done in mice.
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