Lower anxiety and calmer amygdala, a month after one dose
What they did
Twelve healthy volunteers received a single high dose of psilocybin and were scanned while viewing emotional faces at baseline, one week after and one month after.
What they found
One week later, negative mood and amygdala reactivity to emotional faces were reduced. Positive mood stayed elevated at both one week and one month, with trait anxiety lower at one month.
Worth knowing
Twelve people, open-label, no control group. Brain imaging findings in samples this small frequently fail to replicate.
Barrett et al. Emotions and brain function are altered up to one month after a single high dose of psilocybin. Scientific Reports, 2020.
Read the sourceKeep reading
meaningTwo months on, volunteers still called it deeply meaningfulcreativityPsilocybin makes you worse at creativity tests, then bettercognitionEighty-nine healthy people, and no cognitive change at allThe short version is that full doses make you worse at creative tasks while you are on them and slightly better a week later. Anyone selling you focus in a capsule is ahead of the evidence, including anyone selling capsules.
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