Effects rose with dose, and most found the experience pleasant
What they did
Researchers pooled raw data from eight double-blind placebo-controlled studies in which 110 healthy volunteers took oral psilocybin across a wide dose range.
What they found
Effects were dose-dependent and most participants rated the experience as pleasurable. Dysphoria and anxiety occurred in a minority and only at the highest doses, resolving with interpersonal support. Follow-up found no cases of substance abuse, prolonged psychosis or persisting perceptual disturbance.
Worth knowing
Healthy screened volunteers in supervised laboratory settings with support available. That is close to the best possible conditions and not a guide to what happens outside them.
Studerus et al. Acute, subacute and long-term subjective effects of psilocybin in healthy humans. Journal of Psychopharmacology, 2011.
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adverse eventsNo serious harms in healthy people, some in psychiatric patientsharm rankingPsilocybin ranked least harmful of twenty drugs, alcohol mostabuse potentialLow abuse potential, and a case for lighter schedulingThe headline finding worth carrying around is that risk concentrates in people with existing psychiatric conditions and in unsupervised settings. If either applies to you, talk to a doctor before you start anything.
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