meaningFull doseFullStrong evidence

Two months on, volunteers still called it deeply meaningful

Two months on, volunteers still called it one of the most meaningful days of their lives.

2006Published
Double-blind counterbalanced crossover trialStudy type
36 peopleSample
What our evidence ratings mean

What they did

Healthy adults with no prior psychedelic use received a high dose of psilocybin and an active comparator, methylphenidate, in separate supervised eight hour sessions, then were followed up two months later.

What they found

Volunteers rated the psilocybin session as carrying substantial personal meaning and spiritual significance, and reported sustained positive changes in attitude and behaviour that were corroborated by community observers who knew them.

2 monthsbefore the follow-up ratings
36hallucinogen-naive volunteers

Worth knowing

Participants were recruited for regular spiritual practice, which shapes both what they were looking for and how they interpreted it. Personal meaning is a real outcome but not a clinical one.

Griffiths et al. Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacology, 2006.

Read the source

The short version is that full doses make you worse at creative tasks while you are on them and slightly better a week later. Anyone selling you focus in a capsule is ahead of the evidence, including anyone selling capsules.

For education, not medical advice. Every write-up links back to the original source.
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