demoralizationFull doseFullEarly signal

Group therapy and psilocybin eased demoralization in AIDS survivors

Men who had outlived a death sentence, and the demoralization that followed.

2020Published
Open-label safety and feasibility pilotStudy type
18 peopleSample
What our evidence ratings mean

What they did

UCSF paired eight to ten group therapy sessions with a single psilocybin administration for eighteen older gay-identified men living with HIV since before 1996 who carried persistent demoralization.

What they found

Demoralization scores improved meaningfully from baseline to the three month follow-up, with two thirds of participants improving by at least two points and no serious adverse reactions.

2 in 3improved meaningfully

Worth knowing

Open-label with no control group, and the group therapy format means the psilocybin cannot be separated from the effect of the group itself.

Anderson et al. Psilocybin-assisted group therapy for demoralized older long-term AIDS survivor men. eClinicalMedicine, 2020.

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